In a recent study published in the Microorganisms journal, researchers in China reviewed the uses of bacterial-artificial-chromosome (BAC)-based genome editing techniques in herpesvirus research.

Earlier methods to synthesize HAC relied on linking shorter DNA constructs into a larger chromosome within the cell in a process called multimerization. However, the genetic fragments tended to ...

The labs of Julian Sale and Jason Chin at the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge, U.K., have created two new tools critical for rapid genome construction at ...

When constructing bacterial artificial chromosomes (BACs), researchers must verify that they successfully inserted their gene of interest. Because these insertions are large, scientists perform their ...

A human cell undergoing cell division where the goal is to align duplicated chromosomes and deliver a perfect set to the two new “daughter cells.” Image courtesy Ben Black. HACs have wide potential ...

Transposons, or 'jumping genes' -- DNA segments that can move from one part of the genome to another -- are key to bacterial evolution and the development of antibiotic resistance. Researchers have ...

Cost-effective oligo system design schematic. Each synthetic oligo consists of two oligos (oligo-A and oligo-B), one forward primer (Primer-A), and two reverse primers (Primer-B and Primer-C). (A) ...

Transposons are critical drivers of bacterial evolution that have been studied for many decades and have been the subject of Nobel Prize winning research. Now, researchers from Cornell University have ...

Agrobacterium tumefaciens magnified 15,000 times in an image captured earlier this year with a scanning electron microscope at Iowa State University's Roy J. Carver High Resolution Microscopy Facility ...