Aminoacyl-tRNA synthetases (aaRSs) are ubiquitous enzymes that provide the critical link between the genetic code and protein biosynthesis. By precisely catalysing the attachment of amino acids to ...

A team of researchers has uncovered a previously unrecognized role of mitochondrial protein synthesis in the maintenance of intracellular iron distribution. Disruption of this process was found to ...

A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

Protein engineering is a powerful biotechnological process that focuses on creating new enzymes or proteins and improving the functions of existing ones by manipulating their natural macromolecular ...

This mechanism is completely different from the way collagen is broken down by collagen-digesting enzymes in humans and ...

A new method that successfully designs serine hydrolase enzymes capable of catalyzing ester hydrolysis with high efficiency, demonstrates a computational approach for creating de novo enzymes that ...

Reactions that can combine more than two molecular pieces in one go are a powerful way to build complexity quickly and save on costly isolation and purification. But the choreography for such a ...