In human cell tests, these bisphosphonates successfully bound to excess iron, reducing oxidative stress and preventing cell damage. The study offers a potential safer alternative to current iron ...

β-Thalassemia is a genetic disorder characterized by reduced or absent synthesis of the beta chains of hemoglobin, leading to ineffective erythropoiesis and severe anemia. Patients with ...

Sometimes, people with mild thalassemia may be told to supplement with iron. Iron supplements are only appropriate for certain types of thalassemia, though, and can be dangerous for people with more ...

Saturation of TfR1 leads to the dissociation of Hfe and the binding of the alter to the TfR2, which in turn influences the binding of BMP6 to its receptors on the membrane. Increased liver iron ...

Patients with iron overload — serum ferritin > 1000 µg/L or a diagnosis of hemochromatosis or thalassemia — were 60% more likely to have an osteoporotic fracture during an up to 10-year follow-up than ...