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  1. Tumor necrosis factor - Wikipedia

    Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. [5] TNF is produced primarily by activated …

  2. Tumor Necrosis Factor Alpha - an overview - ScienceDirect

    Tumor Necrosis Factor Alpha - an overview - ScienceDirect

  3. TNF Signaling Pathway - Thermo Fisher Scientific - US

    TNF alpha, a pro-inflammatory cytokine, is produced by many cell types, including macrophages, lymphocytes, fibroblasts, and keratinocytes, in response to inflammation, infection, and other …

  4. Human TNF Alpha: Significance in Immunology and Disease

    TNF alpha, primarily produced by activated macrophages, is integral to the immune response. It plays a vital role in systemic inflammation, partaking in cellular signaling that regulates …

  5. TNF-Alpha (Tumor Necrosis Factor): Functions, Test, Normal …

    TNF-alpha is one of the crucial immunological messages that can help your body respond to injury and illness. It is produced by white blood cells and it is quick in triggering inflammation …

  6. The Role of TNF-Alpha in Inflammation and Disease

    Nov 18, 2025 · Tumor Necrosis Factor-alpha (TNF-alpha) is a signaling protein that acts as both a defender against disease and a mediator of chronic illness. It belongs to the class of …

  7. TNF Signaling: Mechanisms, Functions, and Disease

    Jul 26, 2025 · Tumor Necrosis Factor-alpha (TNFα), a member of the TNF family, functions as a primary signaling molecule, or ligand. This protein is primarily secreted by activated immune …

  8. Tumor Necrosis Factor Alpha Signaling and Organogenesis

    Jul 30, 2021 · Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition …

  9. Tumor Necrosis Factor (TNF): How Does It Cause Inflammation? - WebMD

    Oct 9, 2025 · Your system gets flooded with inflammation, which often means you have too much tumor necrosis factor – specifically, a type called TNF alpha.

  10. TNF-Alpha: The Inflammation Signal That Drives Fatigue, Pain, …

    TNF-Alpha, short for Tumor Necrosis Factor Alpha, is one of the main cytokines your immune system uses to turn inflammation on. It goes up during infections and injuries, and it can stay …