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🎙️ HFSA 2025 Interview | Dramatic Cardiovascular Outcomes with Acoramidis in ATTR-CM Dr Ahmad Masri from Oregon Health & Science University shares compelling new analysis from the ATTRibute-CM trial that provides important insights into how and when TTR stabilization therapy benefits patients with transthyretin amyloid cardiomyopathy. 🔬 The Analysis: This post hoc exploratory study examined 611 patients over 30 months, comparing acoramidis 800 mg twice daily to placebo. The patient group had r
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🧬ATTR amyloidosis! New therapies are emerging with diverse mechanisms such as protein stabilization, gene editing, mRNA silencing, and fibril clearance. 1. Tetramer stabilizers (tafamidis/acoramidis) that prevent amyloid formation. 2. CRISPR-Cas9 knockout techniques aiming to delete the problematic gene. 3. siRNA/ASO silencers (patisiran/vutrisiran) that reduce TTR protein production. 4. Monoclonal antibodies (ALXN2220) to clear amyloid deposits. #TTRAmyloidosis #InnovativeTherapies #MedicalRes
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